| http://purl.uniprot.org/citations/11923537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11923537 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary human cells in culture invariably stop dividing and enter a state of growth arrest called replicative senescence. This transition is induced by programmed telomere shortening, but the underlying mechanisms are unclear. Here, we report that overexpression of TRF2, a telomeric DNA binding protein, increased the rate of telomere shortening in primary cells without accelerating senescence. TRF2 reduced the senescence setpoint, defined as telomere length at senescence, from 7 to 4 kilobases. TRF2 protected critically short telomeres from fusion and repressed chromosome-end fusions in presenescent cultures, which explains the ability of TRF2 to delay senescence. Thus, replicative senescence is induced by a change in the protected status of shortened telomeres rather than by a complete loss of telomeric DNA."xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1069523"xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/author | "Smogorzewska A."xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/author | "de Lange T."xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/author | "Karlseder J."xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/pages | "2446-2449"xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/title | "Senescence induced by altered telomere state, not telomere loss."xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/11923537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11923537 |
| http://purl.uniprot.org/citations/11923537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11923537 |
| http://purl.uniprot.org/uniprot/#_Q15554-mappedCitation-11923537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923537 |
| http://purl.uniprot.org/uniprot/Q15554 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11923537 |