| http://purl.uniprot.org/citations/11927551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11927551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11927551 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we present a detailed genetic analysis of let-512/vps34 that encodes the Caenorhabditis elegans homologue of the yeast phosphatidylinositol 3-kinase Vps34p. LET-512/VPS34 has essential functions and is ubiquitously expressed in all tissues and developmental stages. It accumulates at a perinuclear region, and mutations in let-512/vps34 result in an expansion of the outer nuclear membrane as well as in a mislocalization and subsequent complete lack of expression of LRP-1, a C.elegans LDL receptor normally associated with the apical surface of hypodermal cells. Using a GFP::2xFYVE fusion protein we found that the phosphatidylinositol 3-phosphate (PtdIns 3-P) product of LET-512/VPS34 is associated with a multitude of intracellular membranes and vesicles located at the periphery, including endocytic vesicles. We propose that LET-512/VPS34 is required for membrane transport from the outer nuclear membrane towards the cell periphery. Thus, LET-512/VPS34 may regulate the secretory pathway in a much broader range of compartments than was previously suggested for the yeast orthologue."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.7.1673"xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.7.1673"xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Mueller F."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Mueller F."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Bernard V."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Bernard V."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Wymann M.P."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Wymann M.P."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Kovacs A.L."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Kovacs A.L."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Rose A.M."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Rose A.M."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Zetka M."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Zetka M."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Roggo L."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Roggo L."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Savoy F."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/author | "Savoy F."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11927551 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |