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http://purl.uniprot.org/citations/11927565http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11927565http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11927565http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Citation
http://purl.uniprot.org/citations/11927565http://www.w3.org/2000/01/rdf-schema#comment"The genome of Saccharomyces cerevisiae encodes three close homologues of the Escherichia coli 2'-O-rRNA methyltransferase FtsJ/RrmJ, designated Trm7p, Spb1p and Mrm2p. We present evidence that Trm7p methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop, both in vivo and in vitro. In a trm7Delta strain, which is viable but grows slowly, translation is impaired, thus indicating that these tRNA modifications could be important for translation efficiency. We discuss the emergence of a family of three 2'-O-RNA methyltransferases in Eukaryota and one in Prokaryota from a common ancestor. We propose that each eukaryotic enzyme is located in a different cell compartment, in which it would methylate a different RNA that can adopt a very similar secondary structure."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.org/dc/terms/identifier"doi:10.1093/emboj/21.7.1811"xsd:string
http://purl.uniprot.org/citations/11927565http://purl.org/dc/terms/identifier"doi:10.1093/emboj/21.7.1811"xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Bujnicki J.M."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Bujnicki J.M."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Grosjean H."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Grosjean H."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Lecointe F."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Lecointe F."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Pintard L."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Pintard L."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Lapeyre B."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Lapeyre B."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Bonnerot C."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/author"Bonnerot C."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/name"EMBO J."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/name"EMBO J."xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/pages"1811-1820"xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/pages"1811-1820"xsd:string
http://purl.uniprot.org/citations/11927565http://purl.uniprot.org/core/title"Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop."xsd:string