| http://purl.uniprot.org/citations/11927943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11927943 | http://www.w3.org/2000/01/rdf-schema#comment | "The complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/-mice) are highly susceptible to primary infection with influenza virus. C3-/-mice showed delayed viral clearance and increased viral titers in lung, whereas mice deficient for complement receptors CR1 and CR2 (Cr2-/-mice) cleared the infection normally. Priming of T-helper cells and cytotoxic T cells (CTLs) in lung-draining lymph nodes was reduced, and the recruitment into the lung of virus-specific CD4+ and CD8+ effector T cells producing interferon-gamma was severely impaired in C3-/- but not in Cr2-/-mice. Consequently, T-helper cell-dependent IgG responses were reduced in C3-/-mice but remained intact in Cr2-/-mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm0402-373"xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/author | "Kopf M."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/author | "Carroll M."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/author | "Bachmann M.F."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/author | "Gallimore A."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/author | "Abel B."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/pages | "373-378"xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/title | "Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection."xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11927943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11927943 |
| http://purl.uniprot.org/citations/11927943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11927943 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWG3-mappedCitation-11927943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11927943 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWU7-mappedCitation-11927943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11927943 |
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| http://purl.uniprot.org/uniprot/#_E9Q3S5-mappedCitation-11927943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11927943 |
| http://purl.uniprot.org/uniprot/#_Q32M14-mappedCitation-11927943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11927943 |
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