| http://purl.uniprot.org/citations/11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11928811 | http://www.w3.org/2000/01/rdf-schema#comment | "Fischer rat thyroid (FRT) cells organize a matrix of extracellular fibronectin (FN) fibrils, which undergoes extensive remodeling according to cell culture confluence. In non-confluent cells FN forms a fibrillar array associated with the ventral cell surface. However, basal FN is progressively removed in confluent cultures and substituted by non-fibrillar FN deposits at lateral cell domains in regions of cell-cell contacts. FRT cells secrete and expose on the plasma membrane the tissue-type plasminogen activator and, in serum-free cultures, plasminogen induces a rapid loss of FN fibrils. Incubation with plasmin inhibitors greatly reduces this effect. FRT cells also express annexin II, a plasminogen receptor, suggesting that plasmin activity is associated with the pericellular enviroment. This is in agreement with the observation that a great reduction in FN degradation is observed if the cells are pre-incubated with carboxypeptidase B, which prevents plasminogen binding to the cells. A gelatinolytic activity with a molecular weigth equivalent to MMP-2 has been demonstrated by zymography of culture media, and the presence of MMP-2 and MT1-MMP on the cell plasma membrane has been detected by immunofluorescence. These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.org/dc/terms/identifier | "doi:10.1515/bc.2002.017"xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/author | "Nitsch L."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/author | "Greco D."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/author | "Garbi C."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/author | "Nezi L."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/name | "Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/pages | "167-176"xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/title | "The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures."xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/11928811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11928811 |
| http://purl.uniprot.org/citations/11928811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11928811 |
| http://purl.uniprot.org/uniprot/#_A0A096P6L8-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A5M1-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A6KFG4-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A6KFG5-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A6KFG6-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A6KFG7-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_A6KFG8-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_F1LST1-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_P97624-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_P04937-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |
| http://purl.uniprot.org/uniprot/#_Q6LC76-mappedCitation-11928811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11928811 |