| http://purl.uniprot.org/citations/11929775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11929775 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune reconstitution is a critical component of recovery after treatment of human immunodeficiency virus (HIV) infection, cancer chemotherapy, and hematopoietic stem cell transplantation. The ability to enhance T-cell production would benefit such treatment. We examined the effects of exogenous interleukin-7 (IL-7) on apoptosis, proliferation, and the generation of T-cell receptor rearrangement excision circles (TRECs) in human thymus. Quantitative polymerase chain reaction demonstrated that the highest level of TRECs (14 692 copies/10 000 cells) was present in the CD1a(+)CD3(-)CD4(+)CD8(+) stage in native thymus, suggesting that TREC generation occurred following the cellular division in this subpopulation. In a thymic organ culture system, exogenous IL-7 increased the TREC frequency in fetal as well as infant thymus, indicating increased T-cell receptor (TCR) rearrangement. Although this increase could be due to the effect of IL-7 to increase thymocyte proliferation and decrease apoptosis of immature CD3(-) cells, the in vivo experiments using NOD/LtSz-scid mice given transplants of human fetal thymus and liver suggested that IL-7 can also directly enhance TREC generation. Our results provide compelling evidence that IL-7 has a direct effect on increasing TCR-alphabeta rearrangement and indicate the potential use of IL-7 for enhancing de novo naïve T-cell generation in immunocompromised patients."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v99.8.2851"xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/author | "Okamoto Y."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/author | "Koup R.A."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/author | "Douek D.C."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/author | "McFarland R.D."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/pages | "2851-2858"xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/title | "Effects of exogenous interleukin-7 on human thymus function."xsd:string |
| http://purl.uniprot.org/citations/11929775 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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