| http://purl.uniprot.org/citations/11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11929778 | http://www.w3.org/2000/01/rdf-schema#comment | "Costimulatory molecules B7-1 and B7-2 (hereby collectively called B7) interact with CD28 and CTLA4 on T cells and promote antitumor immunity. The function of B7-CTLA4 interaction in antitumor CTL response remains controversial. Here we used CD28(-/-) and CD28(+/-) or CD28(+/+) transgenic mice that express the T-cell receptor specific for an unmutated tumor antigen, P1A, and for tumor cells expressing a CTLA4-specific B7 mutant to evaluate the function of CD28-B7 and CTLA4-B7 interactions in induction and effector phases of antitumor immunity. We report that B7-CD28 and B7-CTLA4 interactions promote tumor rejection. However, this is achieved by distinct mechanisms. B7-CD28 interaction enhances T-cell clonal expansion, though a role for this interaction in the effector phase cannot be ruled out. In contrast, B7-CTLA4 interaction enhances the CTL-mediated destruction of tumors, but not T-cell clonal expansion."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v99.8.2880"xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "Zheng P."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "Bai X.F."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/author | "May K.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/pages | "2880-2889"xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/title | "B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo."xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11929778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11929778 |
| http://purl.uniprot.org/citations/11929778 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11929778 |
| http://purl.uniprot.org/uniprot/#_A0A0X9RAD7-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_P42082-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_P09793-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_Q7TMX1-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_Q8CDB3-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_Q8CH94-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_Q00609-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_P31041-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |
| http://purl.uniprot.org/uniprot/#_Q3TDR5-mappedCitation-11929778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11929778 |