RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/11931740http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11931740http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11931740http://www.w3.org/2000/01/rdf-schema#comment"Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presynaptic development. In neurons, liprin-alpha and LAR-RPTP are enriched at synapses and coimmunoprecipitate with GRIP and AMPA receptors. Dominant-negative constructs that interfere with the GRIP-liprin interaction disrupt the surface expression and dendritic clustering of AMPA receptors in cultured neurons. Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(02)00640-2"xsd:string
http://purl.uniprot.org/citations/11931740http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(02)00640-2"xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Kim E."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Kim E."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Sheng M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Sheng M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Wyszynski M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Wyszynski M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Weinberg R.J."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Weinberg R.J."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Streuli M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Streuli M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Passafaro M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Passafaro M."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Valtschanoff J.G."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Valtschanoff J.G."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Dunah A.W."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Dunah A.W."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Serra-Pages C."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/author"Serra-Pages C."xsd:string
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11931740http://purl.uniprot.org/core/date"2002"xsd:gYear