| http://purl.uniprot.org/citations/11931770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11931770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11931770 | http://www.w3.org/2000/01/rdf-schema#comment | "Negative selection eliminates thymocytes bearing autoreactive T cell receptors (TCR) via an apoptotic mechanism. We have cloned an inhibitor of NF-kappa B, I kappa BNS, which is rapidly expressed upon TCR-triggered but not dexamethasone- or gamma irradiation-stimulated thymocyte death. The predicted protein contains seven ankyrin repeats and is homologous to I kappa B family members. In class I and class II MHC-restricted TCR transgenic mice, transcription of I kappa BNS is stimulated by peptides that trigger negative selection but not by those inducing positive selection (i.e., survival) or nonselecting peptides. I kappa BNS blocks transcription from NF-kappa B reporters, alters NF-kappa B electrophoretic mobility shifts, and interacts with NF-kappa B proteins in thymic nuclear lysates following TCR stimulation. Retroviral transduction of I kappa BNS in fetal thymic organ culture enhances TCR-triggered cell death consistent with its function in selection."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00469-0"xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00469-0"xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Reinherz E.L."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Reinherz E.L."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Marissen W.E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Marissen W.E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Clayton L.K."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Clayton L.K."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Hussey R.E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Hussey R.E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Kruisbeek A.M."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Kruisbeek A.M."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Reche P.A."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Reche P.A."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Tibaldi E.V."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Tibaldi E.V."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Fiorini E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Fiorini E."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Osborn S.L."xsd:string |
| http://purl.uniprot.org/citations/11931770 | http://purl.uniprot.org/core/author | "Osborn S.L."xsd:string |