http://purl.uniprot.org/citations/11934155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11934155 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse Cerberus-like (Cer-l) is a neural inducer molecule, capable of inhibiting Nodal and BMP-4 signals in the extracelular space. The cer-l expression domain in the Anterior Visceral Endoderm (AVE) and prechordal plate, tissues involved in head induction and patterning, respectively, suggested a role for this gene in head formation. However, animals homozygous for the cer-l null allele failed to show any abnormality, leading us to propose the existence of other factor(s) that might compensate for cer-l loss-of-function. Since goosecoid (gsc) shares some domains of expression with cer-l and was shown to be essential for head morphogenesis, we tested its ability to interact genetically with cer-l. With this aim we generated cer-l;gsc double mutants. These animals were analyzed at birth for skeletal defects and revealed the same phenotype as gsc-/-single mutants. We also investigated the proper patterning of structures adjacent to the prechordal plate by performing in situ hybridization of HNF-3beta, Six-3 and BF-1, genes whose expression domains remained unchanged. In conclusion, the analysis carried out indicated that gsc does not compensate for cer-l loss-of-function and that these genes do not interact genetically."xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.org/dc/terms/identifier | "doi:10.1387/ijdb.011496"xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/author | "Marques S."xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/author | "Belo J.A."xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/author | "Borges A.C."xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/name | "Int J Dev Biol"xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/pages | "259-262"xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/title | "Goosecoid and cerberus-like do not interact during mouse embryogenesis."xsd:string |
http://purl.uniprot.org/citations/11934155 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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