http://purl.uniprot.org/citations/11937491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11937491 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced PAK activation. We have also demonstrated that expression of active Rac enhances the ability of plexin-B1 to interact with Sema4D. Active Rac stimulates the localization of plexin-B1 to the cell surface. The enhancement in Sema4D binding depends on the ability of Rac to bind plexin-B1. These observations support a model where signaling between Rac and plexin-B1 is bidirectional; Rac modulates plexin-B1 activity and plexin-B1 modulates Rac function."xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.966402"xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/author | "Vikis H.G."xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/pages | "836-845"xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/title | "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding."xsd:string |
http://purl.uniprot.org/citations/11937491 | http://purl.uniprot.org/core/volume | "16"xsd:string |
http://purl.uniprot.org/citations/11937491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11937491 |
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http://purl.uniprot.org/uniprot/#_A1A4U0-mappedCitation-11937491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11937491 |
http://purl.uniprot.org/uniprot/#_B4DKZ3-mappedCitation-11937491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11937491 |
http://purl.uniprot.org/uniprot/#_O43157-mappedCitation-11937491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11937491 |
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