| http://purl.uniprot.org/citations/11937630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11937630 | http://www.w3.org/2000/01/rdf-schema#comment | "The POU domain transcription factor, Oct-2, is essential for the B cell-specific expression of CD36 in mouse B cells. In order to determine how Oct-2 mediates expression of CD36 in B cells, we cloned and analysed the mouse CD36 promoter. In contrast to the human CD36 promoter, the mouse promoter contains a consensus octamer element of the type ATGCTAAT. This octamer element can be bound by either Oct-1 or Oct-2 but requires the expression of Oct-2 to activate transcription in B cells. Mutation of the octamer element renders the CD36 promoter refractory to activation by Oct-2. Furthermore, we demonstrate that the CD36 octamer element does not support recruitment of the B cell-specific co-activator OBF-1 and that CD36 expression is unaffected in primary B cells derived from obf-1(-/-) mice. We conclude that Oct-2 activates CD36 gene expression in mouse B cells via the octamer element in the promoter. Our data also demonstrate that CD36 is the first example of an Oct-2-dependent gene whose expression in B cells is independent of OBF-1. These findings support the notion that Oct-2 regulates gene transcription by both OBF-1-dependent and -independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/30.8.1767"xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/author | "Corcoran L.M."xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/author | "Dietrich W."xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/author | "Shore P."xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/pages | "1767-1773"xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/title | "Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1."xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/11937630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11937630 |
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| http://purl.uniprot.org/uniprot/P25425#attribution-B6E59A21C7157C935AB443CD421AB67A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11937630 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1Z4-mappedCitation-11937630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11937630 |