| http://purl.uniprot.org/citations/11948194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11948194 | http://www.w3.org/2000/01/rdf-schema#comment | "Alveolar macrophages and newly recruited monocytes are targets of infection by Mycobacterium tuberculosis. Therefore, we examined the expression of interferon regulatory factor 1 (IRF-1), which plays an important role in host defense against M. tuberculosis, in undifferentiated and differentiated cells. Infection induced IRF-1 in both. IRF-1 from undifferentiated, uninfected monocytic cell lines was modified during extraction to produce specific species that were apparently smaller than intact IRF-1. After infection by M. tuberculosis or differentiation, intact IRF-1 was recovered. Subcellular fractions were assayed for the ability to modify IRF-1 or inhibit its modification. A serine protease on the cytoplasmic surface of an organelle or vesicle in the "lysosomal/mitochondrial" fraction from undifferentiated cells was responsible for the modification of IRF-1. Thus, the simplest explanation of the modification is cleavage of IRF-1 by the serine protease. Recovery of intact IRF-1 correlated with induction of a serine protease inhibitor that was able to significantly reduce the modification of IRF-1. The inhibitor was present in the cytoplasm of M. tuberculosis-infected or -differentiated cells. It is likely that induction of both IRF-1 and the serine protease inhibitor in response to infection by M. tuberculosis represent host defense mechanisms."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202965200"xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Prabhakar S."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Coccia E.M."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Giacomini E."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Pine R."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Weiden M."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/author | "Canova A."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/pages | "22377-22385"xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/title | "Host defense responses to infection by Mycobacterium tuberculosis. Induction of IRF-1 and a serine protease inhibitor."xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11948194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11948194 |
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