| http://purl.uniprot.org/citations/11953308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11953308 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute stress provokes lethal cardiac arrhythmias in the hereditary long QT syndrome. Here we provide a novel molecular mechanism linking beta-adrenergic signaling and altered human ether-a-go-go related gene (HERG) channel activity. Stress stimulates beta-adrenergic receptors, leading to cAMP elevations that can regulate HERG K+ channels both directly and via phosphorylation by cAMP-dependent protein kinase (PKA). We show that HERG associates with 14-3-3epsilon to potentiate cAMP/PKA effects upon HERG. The binding of 14-3-3 occurs simultaneously at the N- and C-termini of the HERG channel. 14-3-3 accelerates and enhances HERG activation, an effect that requires PKA phosphorylation of HERG and dimerization of 14-3-3. The interaction also stabilizes the lifetime of the PKA-phosphorylated state of the channel by shielding the phosphates from cellular phosphatases. The net result is a prolongation of the effect of adrenergic stimulation upon HERG activity. Thus, 14-3-3 interactions with HERG may provide a unique mechanism for plasticity in the control of membrane excitability and cardiac rhythm."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.8.1889"xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/author | "McDonald T.V."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/author | "Kagan A."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/author | "Melman Y.F."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/author | "Krumerman A."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/pages | "1889-1898"xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/title | "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity."xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11953308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11953308 |
| http://purl.uniprot.org/citations/11953308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11953308 |
| http://purl.uniprot.org/uniprot/P62258#attribution-24C4F700F5D83A57398B7512AB1BC2AD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/P62258#attribution-306C8055ADA935FFF090DFFEA821A1A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/P62258#attribution-CC66DCF2B6FF05F81CF0841C59875074 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/P62258#attribution-D5B0E4026130F0325D92F6D7672CC949 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/Q04917#attribution-D5B0E4026130F0325D92F6D7672CC949 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/Q12809#attribution-73C7E5EB027C5AF9BD4D2F9FADF7483D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |
| http://purl.uniprot.org/uniprot/Q12809#attribution-CC66DCF2B6FF05F81CF0841C59875074 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11953308 |