| http://purl.uniprot.org/citations/11955436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11955436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11955436 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin precedes and is required for subsequent GSK-3 phosphorylation of beta-catenin. This "priming" kinase is casein kinase Ialpha (CKIalpha). Depletion of CKIalpha inhibits beta-catenin phosphorylation and degradation and causes abnormal embryogenesis associated with excessive Wnt/beta-catenin signaling. Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00685-2"xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00685-2"xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Tan Y."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Tan Y."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Baeg G.-H."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Baeg G.-H."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Semenov M."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/author | "Semenov M."xsd:string |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11955436 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |