| http://purl.uniprot.org/citations/11955610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11955610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11955610 | http://www.w3.org/2000/01/rdf-schema#comment | "Microphthalmia-associated transcription factor (Mitf) regulates the differentiation of melanocytes, optic cup-derived retinal pigment epithelium (RPE), and some types of bone marrow-derived cells. Mitf consists of at least five isoforms with different N-termini, each of which is encoded by a separate exon 1. Here we identified a novel isoform, termed mouse Mitf-D/human MITF-D, that is expressed in RPE, macrophages, and osteoclasts affected by the Mitf mutations, but not expressed in other Mitf target cells, including melanocyte-lineage cells and natural killer cells. The initiation Met of MITF-D is located in the downstream domain (B1b domain) that is shared by other MITF isoforms. The 5'-untranslated region of MITF-D mRNA is encoded by the newly identified first exon of the MITF gene, termed exon 1D, which is located 3 kb upstream of the exon encoding the B1b domain. Thus, the MITF gene generates multiple isoforms with different expression patterns by using the alternative promoters in a cell-dependent manner, thereby providing the molecular basis for the phenotypic variability seen in the MITF/Mitf mutants."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0167-4781(01)00339-6"xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0167-4781(01)00339-6"xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Yasumoto K."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Shibahara S."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Shibahara S."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Kawaguchi N."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Kawaguchi N."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Udono T."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Udono T."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Watanabe K.i."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/author | "Yasumoto K.i."xsd:string |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11955610 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |