| http://purl.uniprot.org/citations/11956668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11956668 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsTo investigate the incidence of the CYP2C19 polymorphism in the Chinese Dai population.MethodsOne hundred and ninety-three healthy Chinese Dai volunteers were identified with respect to CYP2C19 by genotype and phenotype analyses. A polymerase chain reaction-restriction fragment length polymorphism method was performed for genotyping procedures. The 4'-hydroxymephenytoin (4'-OH-MP) and S/R-mephenytoin ( S/R-MP) excreted in the urine were determined by high-performance liquid chromatography and gas chromatography, respectively.ResultsEighteen subjects were identified as poor metabolisers (PMs). The frequency of PMs in the Chinese Dai subjects was 9.3% (95% confidence interval 5.2, 13.4), which is lower than that in the Chinese Han population ( P<0.05). Chinese Dai subjects had a higher frequency of the mutant CYP2C19*2 allele (0.303) and a lower frequency of the mutant CYP2C19*3 allele (0.034). These two mutant alleles could explain all deficiencies of CYP2C19 activity in the Chinese Dai subjects. The frequency of the CYP2C19*3 allele is significantly lower than that in the Chinese Han population ( P<0.05). The mean S/R ratio was lower in the homozygous extensive metabolisers (EMs) compared with that in heterozygous EMs ( P<0.01), and the latter was lower than that in the PMs ( P<0.01). Furthermore, the mean S/R ratio in CYP2C19*3/ CYP2C19*2 heterozygous PMs was possibly lower than that in the CYP2C19*2/ CYP2C19*2 homozygous PMs ( P<0.05).ConclusionThe frequencies of PMs and CYP2C19*3 allele in the Chinese Dai population are significantly lower than those in the Han population. The CYP2C19 genotype analysis is largely consistent with the mephenytoin phenotype analysis. The variability of S/R ratios in EMs and PMs shows a gene-dosage effect."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00228-002-0425-x"xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "He N."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Huang S.L."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Liu Z.Q."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Xiao Z.S."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Zhou H.H."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/author | "Yan F.X."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/name | "Eur J Clin Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/pages | "15-18"xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/title | "CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population."xsd:string |
| http://purl.uniprot.org/citations/11956668 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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