| http://purl.uniprot.org/citations/11970895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11970895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11970895 | http://www.w3.org/2000/01/rdf-schema#comment | "Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00140-5"xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00140-5"xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Miller J.R."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Miller J.R."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Takemaru K."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Takemaru K."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Earnest T.N."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Earnest T.N."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Fox E.P."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Fox E.P."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Cheyette B.N.R."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Cheyette B.N.R."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Khlebtsova N."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Khlebtsova N."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Sheldahl L.C."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Sheldahl L.C."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Waxman J.S."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/author | "Waxman J.S."xsd:string |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11970895 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |