| http://purl.uniprot.org/citations/11971901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11971901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11971901 | http://www.w3.org/2000/01/rdf-schema#comment | "The IkappaB kinase (IKK) complex includes the catalytic components IKKalpha and IKKbeta in addition to the scaffold protein IKKgamma/NEMO. Increases in the activity of the IKK complex result in the phosphorylation and subsequent degradation of IkappaB and the activation of the NF-kappaB pathway. Recent data indicate that the constitutive activation of the NF-kappaB pathway by the human T-cell lymphotrophic virus, type I, Tax protein leads to enhanced phosphorylation of IKKgamma/NEMO by IKKbeta. To address further the significance of IKKbeta-mediated phosphorylation of IKKgamma/NEMO, we determined the sites in IKKgamma/NEMO that were phosphorylated by IKKbeta, and we assayed whether IKKgamma/NEMO phosphorylation was involved in modulating IKKbeta activity. IKKgamma/NEMO is rapidly phosphorylated following treatment of cells with stimuli such as tumor necrosis factor-alpha and interleukin-1 that activate the NF-kappaB pathway. By using both in vitro and in vivo assays, IKKbeta was found to phosphorylate IKKgamma/NEMO predominantly in its carboxyl terminus on serine residue 369 in addition to sites in the central region of this protein. Surprisingly, mutation of these carboxyl-terminal serine residues increased the ability of IKKgamma/NEMO to stimulate IKKbeta kinase activity. These results indicate that the differential phosphorylation of IKKgamma/NEMO by IKKbeta and perhaps other kinases may be important in regulating IKK activity."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201393200"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201393200"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/author | "Gaynor R.B."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/author | "Prajapati S."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/author | "Prajapati S."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/pages | "24331-24339"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/pages | "24331-24339"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/title | "Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/title | "Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11971901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11971901 |
| http://purl.uniprot.org/citations/11971901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11971901 |
| http://purl.uniprot.org/citations/11971901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11971901 |
| http://purl.uniprot.org/citations/11971901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11971901 |
| http://purl.uniprot.org/uniprot/O88522 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11971901 |
| http://purl.uniprot.org/uniprot/O88522#attribution-06F6966927D6535C4D738763EE022E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11971901 |