| http://purl.uniprot.org/citations/11973295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11973295 | http://www.w3.org/2000/01/rdf-schema#comment | "The Saccharomyces cerevisiae MGM101 gene encodes a DNA-binding protein targeted to mitochondrial nucleoids. MGM101 is essential for maintenance of a functional rho(+) genome because meiotic segregants, with a disrupted mgm101 allele, cannot undergo more than 10 divisions on glycerol medium. Quantitative analysis of mtDNA copy number in a rho(+) strain carrying a temperature-sensitive allele, mgm101-1, revealed that the amount of mtDNA is halved each cell division upon a shift to the restrictive temperature. These data suggest that mtDNA replication is rapidly blocked in cells lacking MGM101. However, a small proportion of meiotic segregants, disrupted in MGM101, have rho(-) genomes that are stably maintained. Interestingly, all surviving rho(-) mtDNAs contain an ori/rep sequence. Disruption of MGM101 in hypersuppressive (HS) strains does not have a significant effect on the propagation of HS rho(-) mtDNA. However, in petites lacking an ori/rep, disruption of MGM101 leads to either a complete loss or a dramatically decreased stability of mtDNA. This discriminatory effect of MGM101 suggests that replication of rho(+) and ori/rep-devoid rho(-) mtDNAs is carried out by the same process. By contrast, the persistence of ori/rep-containing mtDNA in HS petites lacking MGM101 identifies a distinct replication pathway. The alternative mtDNA replication mechanism provided by ori/rep is independent of mitochondrial RNA polymerase encoded by RPO41 as a HS rho(-) genome is stably maintained in a mgm101, rpo41 double mutant."xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/160.4.1389"xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/author | "Chen X.J."xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/author | "Clark-Walker G.D."xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/author | "Zuo X.M."xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/pages | "1389-1400"xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/title | "The mitochondrial nucleoid protein, Mgm101p, of Saccharomyces cerevisiae is involved in the maintenance of rho(+) and ori/rep-devoid petite genomes but is not required for hypersuppressive rho(-) mtDNA."xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/11973295 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11973295 |
| http://purl.uniprot.org/citations/11973295 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11973295 |
| http://purl.uniprot.org/uniprot/#_P13433-mappedCitation-11973295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11973295 |
| http://purl.uniprot.org/uniprot/#_P32787-mappedCitation-11973295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11973295 |
| http://purl.uniprot.org/uniprot/P32787 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11973295 |
| http://purl.uniprot.org/uniprot/P13433 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11973295 |