| http://purl.uniprot.org/citations/11973348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11973348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11973348 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report we have characterized a novel, ubiquitously expressed kinase, Clik1, that is predominantly nuclear and undergoes autophosphorylation. Yeast two-hybrid analysis indicated a highly specific association between Clik1 and CLP-36, which was identified in 36 out of 37 Clik1-interacting clones. CLP-36 is a PDZ-LIM protein that localizes to actin stress fibers in nonmuscle cells and associates with alpha-actinin via its PDZ-domain. The association of CLP-36 with Clik1, in turn, is mediated by the C-terminal part of CLP-36 containing the LIM domain, and association was not noted with the closely related ALP PDZ-LIM protein. Interestingly, the association with CLP-36 led to relocalization of the otherwise nuclear Clik1 kinase to actin stress fibers, where it disrupted the periodic staining pattern of CLP-36. Taken together these results establish the CLP-36 PDZ-LIM protein as an adapter, recruiting the Clik1 kinase to actin stress fibers in nonmuscle cells, and suggest that Clik1 represents a novel regulator of actin stress fibers."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115.10.2067"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115.10.2067"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/author | "Maekelae T.P."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/author | "Maekelae T.P."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/author | "Vallenius T."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/author | "Vallenius T."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/pages | "2067-2073"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/pages | "2067-2073"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/title | "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/title | "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein."xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/11973348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11973348 |
| http://purl.uniprot.org/citations/11973348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11973348 |
| http://purl.uniprot.org/citations/11973348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11973348 |
| http://purl.uniprot.org/citations/11973348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11973348 |
| http://purl.uniprot.org/uniprot/Q8TDR2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11973348 |
| http://purl.uniprot.org/uniprot/Q8TDR2#attribution-A30DB523B9E93C432F9B15DE9E703B24 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11973348 |