| http://purl.uniprot.org/citations/11976265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11976265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11976265 | http://www.w3.org/2000/01/rdf-schema#comment | "Efaroxan induces membrane depolarization by interaction with the pore forming subunit of the ATP-sensitive potassium channel, Kir6.2. However, this effect is not responsible for its full secretory activity. In this study we have used an anti-idiotypic approach to generate antibodies that recognize additional proteins that may be regulated by efaroxan in pancreatic beta-cells. Using these antisera in an expression cloning strategy we have identified a monomeric GTP-binding protein, Rhes, as a potential target for regulation by imidazoline ligands. Rhes is shown to be expressed in beta-cells and its expression is regulated by efaroxan under conditions when a structurally related molecule, KU14R, is ineffective. The results reveal that beta-cells express Rhes and suggest that changes in the expression of this molecule may regulate the sensitivity of beta-cells to imidazoline secretagogues."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjp.0704680"xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjp.0704680"xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Morgan N.G."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Morgan N.G."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Chan S.L.F."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Chan S.L.F."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Deaville P."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Deaville P."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Monks L.K."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/author | "Monks L.K."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/name | "Br. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/name | "Br. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/pages | "31-36"xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/pages | "31-36"xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/title | "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/title | "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell."xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/11976265 | http://purl.uniprot.org/core/volume | "136"xsd:string |