| http://purl.uniprot.org/citations/11980719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980719 | http://www.w3.org/2000/01/rdf-schema#comment | "Mature macrophages, neutrophils and lymphoid cells do not develop in PU.1(-/-) mice. In contrast, mice lacking the highly related protein Spi-B generate all hematopoietic lineages but display a B-cell receptor signaling defect. These distinct phenotypes could result from functional differences between PU.1 and Spi-B or their unique temporal and tissue-specific expression (PU.1: myeloid and B cells; Spi-B: B cells only). To address this question, we introduced the Spi-B cDNA into the murine PU.1 locus by homologous recombination. In the absence of PU.1, Spi-B rescued macrophage and granulocyte development when assayed by in vitro differentiation of embryonic stem cells. Adherent, CD11b(+)/F4/80(+) cells capable of phagocytosis were detected in PU.1(Spi-B/Spi-B) embryoid bodies, and myeloid colonies were present in hematopoietic progenitor assays. Despite its ability to rescue myeloid differentiation, Spi-B did not rescue lymphoid development in a RAG-2(-/-) complementation assay. These results demonstrate an important difference between PU.1 and Spi-B. Careful comparison of these Ets factors will delineate important functional domains of PU.1 involved in lymphocyte lineage commitment and/or maturation."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.9.2220"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.9.2220"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Rao S."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Rao S."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Simon M.C."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Simon M.C."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Dahl R."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Dahl R."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Ramirez-Bergeron D.L."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/author | "Ramirez-Bergeron D.L."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/pages | "2220-2230"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/pages | "2220-2230"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/title | "Spi-B can functionally replace PU.1 in myeloid but not lymphoid development."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/title | "Spi-B can functionally replace PU.1 in myeloid but not lymphoid development."xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11980719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11980719 |
| http://purl.uniprot.org/citations/11980719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11980719 |