Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11980884http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To examine the involvement of c-Jun and c-Jun N-terminal phosphorylation (JNP) in apoptosis of retinal ganglion cells (RGCs) after the optic nerve (ON) transection.

Methods

The expression and phosphorylation of c-Jun protein and apoptosis in RGCs were examined after ON transection in wild-type mice and mice in which both phosphoacceptor serines of Jun have mutated to alanines (c-Jun[AA] mice). The fluorescent tracer 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) was applied to the superior colliculi (SC), and the right ON was severed after 7 days. After two more weeks, the average number of RGCs per field was calculated.

Results

JNP and TUNEL-labeled apoptotic nuclei were detected in the ganglion cell layer (GCL) of the retina of the wild-type mice in response to ON transection. The numbers of TUNEL-positive nuclei in the c-Jun(AA) mice was reduced in comparison to those in wild-type mice. Retrograde labeling showed that the number of the RGCs in the retinas on the injured side of the c-Jun(AA) mice was significantly higher than in wild-type mice 14 days after the lesion.

Conclusions

These results suggest that there is a partial but significant contribution of JNP to the induction of apoptosis in RGCs by ON transection."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Harada T."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Ohno S."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Yoshida K."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Wagner E.F."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Karin M."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Behrens A."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Le-Niculescu H."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/author"Imaki J."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/name"Invest Ophthalmol Vis Sci"xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/pages"1631-1635"xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/title"Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection."xsd:string
http://purl.uniprot.org/citations/11980884http://purl.uniprot.org/core/volume"43"xsd:string
http://purl.uniprot.org/citations/11980884http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11980884
http://purl.uniprot.org/citations/11980884http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11980884
http://purl.uniprot.org/uniprot/#_Q52L79-mappedCitation-11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/#_Q3V255-mappedCitation-11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/#_P05627-mappedCitation-11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/#_Q3US19-mappedCitation-11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/#_Q6TDG5-mappedCitation-11980884http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/P05627http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/Q52L79http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/11980884
http://purl.uniprot.org/uniprot/Q6TDG5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/11980884
▶