| http://purl.uniprot.org/citations/11980899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980899 | http://www.w3.org/2000/01/rdf-schema#comment | "Respiratory syncytial virus (RSV), associated with bronchiolitis and asthma, is resistant to the antiviral effects of type-I interferons (IFN), but not IFN-gamma. However, the antiviral mechanism of IFN-gamma action against RSV infection is unknown. The molecular mechanism of IFN-gamma-induced antiviral activity was examined in this study using human epithelial cell lines HEp-2 and A549. Exposure of these cells to 100-1000 units/ml of IFN-gamma, either before or after RSV infection, results in a significant decrease in RSV infection. After 1 h of exposure, IFN-gamma induces protein expression of IFN regulatory factor-1 (IRF-1) but not IRF-2, double-stranded RNA-activated protein kinase, and inducible nitric-oxide synthase in these cells. The mRNA for IRF-1, p40, and p69 isoforms of 2'-5' oligoadenylate synthetase (2-5 AS) are detectable, respectively, at 1 and 4 h of IFN-gamma exposure. Studies using cycloheximide and antisense oligonucleotides to IRF-1 indicate a direct role of IRF-1 in activating 2-5 AS. Cells transfected with 2-5 AS antisense oligonucleotides inhibit the antiviral effect of IFN-gamma. A stable cell line of HEp-2 overexpressing RNase L inhibitor, RLI-14, which exhibits an IFN-gamma-induced gene expression pattern similar to that of the parent cell line, shows a significant reduction in RNase L activity and IFN-gamma-mediated antiviral effect, compared with HEp-2 cells. These results provide direct evidence of the involvement of 2-5 AS in IFN-gamma-mediated antiviral activity in these cells."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200211200"xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/author | "Lockey R.F."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/author | "Mohapatra S.S."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/author | "Behera A.K."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/pages | "25601-25608"xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/title | "2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11980899 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11980899 |
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| http://purl.uniprot.org/uniprot/#_A7YIG8-mappedCitation-11980899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11980899 |
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