| http://purl.uniprot.org/citations/11980909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980909 | http://www.w3.org/2000/01/rdf-schema#comment | "The E2F family of transcription factors controls the expression of numerous genes that are required for the G(1)/S transition. Among the mechanisms that modulate the activity of the E2F proteins, cyclin A has been found to be important for the down-regulation of E2F-1, -2, and -3A activity after cells have progressed through G(1)/S. Specifically, phosphorylation of these E2F proteins by cyclin A/Cdk2 ultimately results in their necessary degradation as cells progress through S phase. E2F-3B was recently identified as an alternatively spliced form of E2F-3A that was predicted to lack a functional cyclin A binding domain. In this paper, we present considerable evidence that contradicts this prediction. First, we demonstrate binding of cyclin A to E2F-3B as bacterially expressed proteins in vitro. Second, we demonstrate binding of cyclin A to E2F-3B in mammalian cells in vivo. Third, we show that co-expression of cyclin A with E2F-3B significantly reduces E2F-3B-mediated transcriptional activity. Finally, in synchronized cells, we observe down-regulation of E2F-3B protein expression coincident with the up-regulation of cyclin A. We conclude that E2F-3B is a physiological target of cyclin A."xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202629200"xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/author | "Cress W.D."xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/pages | "23493-23499"xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/title | "E2F-3B is a physiological target of cyclin A."xsd:string |
| http://purl.uniprot.org/citations/11980909 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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