| http://purl.uniprot.org/citations/11983897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11983897 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to its important functions in detoxification of foreign chemicals and biosynthesis of steroid hormones, the cytochrome P450 enzyme system metabolizes arachidonate to 14,15-epoxyeicosatrienoic acid (14,15-EET). This study demonstrates that a P450 arachidonate epoxygenase metabolite can activate cleavage of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and delineates an essential role for HB-EGF in the mitogenic effects of this lipid mediator. Blockade of HB-EGF processing or EGF receptor (EGFR) inhibited 14,15-EET-stimulated early mitogenic signals and DNA synthesis. 14,15-EET failed to induce mitogenesis in cell lines expressing minimal HB-EGF, whereas 14,15-EET induced soluble HB-EGF release into the conditioned media of cell lines that both express high levels of HB-EGF and display mitogenic response to this lipid mediator. Moreover, transfection of a bacterial 14,15-epoxygenase established intracellular endogenous 14,15-EET biosynthesis in cultured cell systems, which allowed direct confirmation of involvement of EGFR transactivation in the endogenous 14,15-EET-mediated mitogenic signaling pathway. This mechanism involves EET-dependent activation of metalloproteinases and release of the potent mitogenic EGFR ligand, HB-EGF."xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.092671899"xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/author | "Harris R.C."xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/author | "Capdevila J."xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/author | "Chen J.K."xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/pages | "6029-6034"xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/title | "Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/11983897 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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