| http://purl.uniprot.org/citations/11985796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11985796 | http://www.w3.org/2000/01/rdf-schema#comment | "Early detection of hepatocellular carcinoma (HCC) is clinically important because advanced HCC limits treatment modalities for the cancer. We have previously reported that serum levels of MAGE-4 protein are strongly associated with the development of HCC. The present study was designed to determine whether elevated serum MAGE-4 protein levels can predict hepatocellular carcinogenesis in patients with liver cirrhosis before clinical diagnosis. Among 62 cirrhotic patients, 28 patients were diagnosed with HCC during the follow-up period. The levels of MAGE-4 protein and alpha-fetoprotein (AFP) were significantly elevated in cirrhotic patients with HCC. Univariate and multivariate analyses suggest that elevated serum MAGE-4 protein is more significant than AFP. Importantly, retrospective analysis of prefrozen sera of cirrhotic patients revealed a transient or continuous elevation of serum MAGE-4 protein levels in 14 of 28 cirrhotic patients with HCC (50%) before clinical diagnosis. In contrast, elevated serum MAGE-4 protein levels were observed in 3 of 33 cirrhotic patients without HCC (9%), and in 2 of 34 hepatitic patients (6%). These results indicate that elevated serum MAGE-4 protein levels can be a predictive marker of hepatocellular carcinogenesis in cirrhotic patients, thereby enabling us to treat patients at an earlier stage."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2002.tb01277.x"xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Harada M."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Itoh K."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Shichijo S."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Imai N."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Sata M."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Yutani S."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/author | "Mutsumoto H."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/name | "Jpn J Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/pages | "453-458"xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/title | "Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis."xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/11985796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11985796 |
| http://purl.uniprot.org/citations/11985796 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11985796 |
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| http://purl.uniprot.org/uniprot/P43358 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11985796 |
| http://purl.uniprot.org/uniprot/Q4V9T5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11985796 |
| http://purl.uniprot.org/uniprot/B4DTE6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11985796 |