| http://purl.uniprot.org/citations/11988176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11988176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11988176 | http://www.w3.org/2000/01/rdf-schema#comment | "Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons. Neuronal H(+)-gated currents and transient acidification are proposed to play a role in synaptic transmission. Investigating this possibility, we found ASIC in hippocampus, in synaptosomes, and in dendrites localized at synapses. Moreover, loss of ASIC impaired hippocampal long-term potentiation. ASIC null mice had reduced excitatory postsynaptic potentials and NMDA receptor activation during high-frequency stimulation. Consistent with these findings, null mice displayed defective spatial learning and eyeblink conditioning. These results identify ASIC as a key component of acid-activated currents and implicate these currents in processes underlying synaptic plasticity, learning, and memory."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)00661-x"xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)00661-x"xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Wemmie J.A."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Wemmie J.A."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Askwith C.C."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Askwith C.C."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Freeman J.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Freeman J.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Hruska-Hageman A.M."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Hruska-Hageman A.M."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Lamani E."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Lamani E."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Nolan B.C."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Nolan B.C."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Price M.P."xsd:string |
| http://purl.uniprot.org/citations/11988176 | http://purl.uniprot.org/core/author | "Price M.P."xsd:string |