| http://purl.uniprot.org/citations/11998972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11998972 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiotensin II (Ang II) is central to the pathobiology of atherosclerosis. In endothelial cells (EC), Ang II induces apoptosis. The MAP kinase ERK1/2 plays a key role in regulating cell survival. We therefore investigated the effect of Ang II on ERK1/2. Incubation of EC with Ang II led to the dephosphorylation of ERK1/2 (43% of control). To characterize the phosphatase involved, we investigated the effect of Ang II on MAP kinase phosphatase expression. Ang II induced MAP kinase phosphatase-3 (MKP-3) mRNA levels to about 2-fold, whereas MKP-1 expression was not affected. Transfection with a dominant negative MKP-3 construct (dnMKP-3mt) prevented the Ang II-induced ERK1/2 dephosphorylation and apoptosis in EC (p < 0.001). ERK1/2 inactivation has been shown to result in the dephosphorylation and proteasomal degradation of the antiapoptotic protein Bcl-2. Ang II induced the degradation of Bcl-2 wild type, whereas the dephosphorylation-resistant Bcl-2 construct mimicking phosphorylation by ERK1/2 was resistant to Ang II stimulation. These results indicate that Ang II-induced apoptosis signaling in human EC is mediated via MKP-3-dependent dephosphorylation of ERK1/2, which in turn leads to the degradation of Bcl-2."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.org/dc/terms/identifier | "doi:10.1007/s395-002-8381-2"xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Dimmeler S."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Zeiher A.M."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Hermann C."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Haendeler J."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Rossig L."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/author | "Assmus B."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/name | "Basic Res Cardiol"xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/title | "Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/11998972 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11998972 |
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