| http://purl.uniprot.org/citations/12001066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12001066 | http://www.w3.org/2000/01/rdf-schema#comment | "The Notch signaling pathway is important in regulating formation and anterior-posterior patterning of somites in vertebrate embryos. Here we show that distinct segmentation defects are displayed in embryos mutant for the Notch pathway genes Notch1, Lunatic fringe (Lfng), Delta-like 1 (Dll1), and Delta-like 3 (Dll3). Lfng-deficient mice and Dll3-deficient mice exhibit very similar defects, and marker analysis suggests that progression of the segmentation clock is disrupted in Dll3 mutants. We also show that Radical fringe (Rfng)-deficient mice exhibit no obvious phenotypic defects. To assess whether the absence of a phenotype in Rfng-deficient mice was the result of functional redundancy with the Lfng gene, we generated Lfng/Rfng double homozygous mutant mice. These mice exhibit the skeletal defects normally observed in Lfng-deficient mice, but we detected no obvious synergistic or additive effects in the double mutant animals."xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.org/dc/terms/identifier | "doi:10.1002/gene.10081"xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/author | "Gridley T."xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/author | "Norton C.R."xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/name | "Genesis"xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/pages | "21-28"xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/title | "Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice."xsd:string |
| http://purl.uniprot.org/citations/12001066 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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| http://purl.uniprot.org/uniprot/#_O09009-mappedCitation-12001066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12001066 |