| http://purl.uniprot.org/citations/12004067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12004067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12004067 | http://www.w3.org/2000/01/rdf-schema#comment | "Nerve terminals release neurotransmitters from vesicles into the synaptic cleft upon transient increases in intracellular Ca(2+). This exocytotic process requires the formation of trans SNARE complexes and is regulated by accessory proteins including the complexins. Here we report the crystal structure of a squid core complexin-SNARE complex at 2.95-A resolution. A helical segment of complexin binds in anti-parallel fashion to the four-helix bundle of the core SNARE complex and interacts at its C terminus with syntaxin and synaptobrevin around the ionic zero layer of the SNARE complex. We propose that this structure is part of a multiprotein fusion machinery that regulates vesicle fusion at a late pre-fusion stage. Accordingly, Ca(2+) may initiate membrane fusion by acting directly or indirectly on complexin, thus allowing the conformational transitions of the trans SNARE complex that are thought to drive membrane fusion."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203460200"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203460200"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M203460200"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Betz H."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Betz H."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Bracher A."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Bracher A."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Weissenhorn W."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Weissenhorn W."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Kadlec J."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/author | "Kadlec J."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/pages | "26517-26523"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/pages | "26517-26523"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/title | "X-ray structure of a neuronal complexin-SNARE complex from squid."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/title | "X-ray structure of a neuronal complexin-SNARE complex from squid."xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12004067 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12004067 |