| http://purl.uniprot.org/citations/12004076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12004076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12004076 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability. pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent. The 1.85 angstrom structure of a 20-residue HIF-1alpha peptide-pVHL-ElonginB-ElonginC complex shows that HIF-1alpha binds to pVHL in an extended beta strand-like conformation. The hydroxyproline inserts into a gap in the pVHL hydrophobic core, at a site that is a hotspot for tumorigenic mutations, with its 4-hydroxyl group recognized by buried serine and histidine residues. Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073440"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073440"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Gertler F."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Gertler F."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Min J.-H."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Min J.-H."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Ivan M."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/author | "Ivan M."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/pages | "1886-1889"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/pages | "1886-1889"xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/title | "Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."xsd:string |
| http://purl.uniprot.org/citations/12004076 | http://purl.uniprot.org/core/title | "Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."xsd:string |