| http://purl.uniprot.org/citations/12007404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12007404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12007404 | http://www.w3.org/2000/01/rdf-schema#comment | "Defining the molecular mechanisms that coordinately regulate proliferation and differentiation is a central issue in development. Here, we describe a mechanism in which induction of the Ets repressor METS/PE1 links terminal differentiation to cell cycle arrest. Using macrophages as a model, we provide evidence that METS/PE1 blocks Ras-dependent proliferation without inhibiting Ras-dependent expression of cell type-specific genes by selectively replacing Ets activators on the promoters of cell cycle control genes. Antiproliferative effects of METS require its interaction with DP103, a DEAD box-containing protein that assembles a novel corepressor complex. Functional interactions between the METS/DP103 complex and E2F/ pRB family proteins are also necessary for inhibition of cellular proliferation, suggesting a combinatorial code that directs permanent cell cycle exit during terminal differentiation."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00714-6"xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00714-6"xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0092-8674(02)00714-6"xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Jacks T."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Jacks T."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Sage J."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Sage J."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Kamps M.P."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Kamps M.P."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Sykes D.B."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Sykes D.B."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Brard G."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Brard G."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Gangadharan D."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Gangadharan D."xsd:string |
| http://purl.uniprot.org/citations/12007404 | http://purl.uniprot.org/core/author | "Klappacher G.W."xsd:string |