| http://purl.uniprot.org/citations/12009529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12009529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12009529 | http://www.w3.org/2000/01/rdf-schema#comment | "An unbiased functional screening with brain cDNA library from an Alzheimer's disease (AD) brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related neurotoxicity. As the 1567-base cDNA containing the open reading frame (ORF) of HN is 99% identical to mitochondrial 16S ribosomal RNA as well as registered human mRNA, it was elusive whether HN is produced in vivo. Here, we raised anti-HN antibody and found that long cDNAs containing the ORF of HN (HN-ORF) produced the HN peptide in mammalian cells, dependent on the presence of full-length HN-ORF. Immunoblot analysis detected a 3-kDa protein with HN immunoreactivity in the testis and the colon in 3-week-old mice and in the testis in 12-week-old mice. HN immunoreactivity was also detected in an AD brain, but little in normal brains. This study suggests that HN peptide could be produced in vivo, and would provide a novel insight into the pathophysiology of AD."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0304-3940(02)00199-4"xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0304-3940(02)00199-4"xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Hashimoto Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Hashimoto Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Niikura T."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Niikura T."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Yamazaki K."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Yamazaki K."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Kita Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Kita Y."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Nishimoto I."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Nishimoto I."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Tajima H."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Tajima H."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Aiso S."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Aiso S."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Koto A."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Koto A."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Terashita K."xsd:string |
| http://purl.uniprot.org/citations/12009529 | http://purl.uniprot.org/core/author | "Terashita K."xsd:string |