| http://purl.uniprot.org/citations/12009866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12009866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12009866 | http://www.w3.org/2000/01/rdf-schema#comment | "The negative factor (Nef) is one of six accessory proteins from primate lentiviruses (HIV-1, HIV-2, and SIV). It leads to high levels of viremia and the progression to AIDS in monkeys and humans. In this study, we demonstrated that Nef from HIV-1 binds to the regulatory subunit (p85) of phosphatidylinositol-3-kinase (PI3K). This interaction depended on the C-terminus of p85 and Nef. Moreover, PI3K was required to activate the Nef-associated p21-activated kinase (PAK). Finally, inhibition of PI3K blocked the activation of PAK and decreased the production of viral particles to levels observed with the Nef-deleted provirus. We conclude that Nef assembles a multiprotein signaling complex which is required for the optimal replication of HIV-1."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.2002.1365"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.2002.1365"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Zheng Y.-H."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Zheng Y.-H."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Linnemann T."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Linnemann T."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Mandic R."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/author | "Mandic R."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/pages | "246-255"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/pages | "246-255"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/title | "Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/title | "Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV."xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/12009866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12009866 |
| http://purl.uniprot.org/citations/12009866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12009866 |