| http://purl.uniprot.org/citations/12011060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12011060 | http://www.w3.org/2000/01/rdf-schema#comment | "GATA-4, -5, and -6 zinc finger and hepatocyte nuclear factor-1alpha (HNF-1alpha) homeodomain transcription factors are expressed in the intestinal epithelium and synergistically activate the promoter of intestinal genes. Here, we demonstrate that GATA-5 and HNF-1alpha physically associate both in vivo and in vitro and that this interaction is necessary for cooperative activation of the lactase-phlorizin hydrolase promoter. Furthermore, physical association is mediated by the C-terminal zinc finger of GATA factors and the homeodomain of HNF-1alpha. Deletion of HNF-1alpha activation domains or interruption of HNF-1-binding sites in the lactase-phlorizin hydrolase promoter resulted in a complete loss of cooperativity, whereas deletion of GATA-5 activation domains or interruption of GATA-binding sites resulted in a reduction, but not an elimination, of cooperativity. We hypothesize that GATA/HNF-1alpha cooperativity is mediated by HNF-1alpha through its activation domains, which are oriented for high levels of activation through binding to DNA and physical association with GATA factors. These data suggest a paradigm whereby intestine-specific gene expression is regulated by unique interactions among tissue-restricted transcription factors coexpressed in the intestine. Parallel mechanisms in other tissues as well as in Drosophila suggest that zinc finger/homeodomain interactions are an efficient pathway of cooperative activation of gene transcription that has been conserved throughout evolution."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203645200"xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Boudreau F."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Rings E.H."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Grand R.J."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Krasinski S.D."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Dowling L.N."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "Huibregtse I.L."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "de Bie M.S."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "van Wering H.M."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/author | "van der Zwan S.M."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/pages | "27659-27667"xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/title | "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter."xsd:string |
| http://purl.uniprot.org/citations/12011060 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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