| http://purl.uniprot.org/citations/12011424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12011424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12011424 | http://www.w3.org/2000/01/rdf-schema#comment | "Triple-helical collagen IV protomers associate through their N- and C-termini forming a three-dimensional network, which provides basement membranes with an anchoring scaffold and mechanical strength. The noncollagenous (NC1) domain of the C-terminal junction between two adjacent collagen IV protomers from human placenta was crystallized and its 1.9-A structure was solved by multiple anomalous diffraction (MAD) phasing. This hexameric NC1 particle is composed of two trimeric caps, which interact through a large planar interface. Each cap is formed by two alpha 1 fragments and one alpha 2 fragment with a similar previously uncharacterized fold, segmentally arranged around an axial tunnel. Each monomer chain folds into two structurally very similar subdomains, which each contain a finger-like hairpin loop that inserts into a six-stranded beta-sheet of the neighboring subdomain of the same or the adjacent chain. Thus each trimer forms a quite regular, but nonclassical, sixfold propeller. The trimer-trimer interaction is further stabilized by a previously uncharacterized type of covalent cross-link between the side chains of a Met and a Lys residue of the alpha 1 and alpha 2 chains from opposite trimers, explaining previous findings of nonreducible cross-links in NC1. This structure provides insights into NC1-related diseases such as Goodpasture and Alport syndromes."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.062183499"xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.062183499"xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bartunik H.D."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bartunik H.D."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bourenkov G.P."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bourenkov G.P."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Mann K."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Mann K."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bode W."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Bode W."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Than M.E."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Than M.E."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Ries A."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Ries A."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Kuhn K."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Kuhn K."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Timpl R."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Timpl R."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Henrich S."xsd:string |
| http://purl.uniprot.org/citations/12011424 | http://purl.uniprot.org/core/author | "Henrich S."xsd:string |