| http://purl.uniprot.org/citations/12016213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12016213 | http://www.w3.org/2000/01/rdf-schema#comment | "X11 proteins have been shown to modulate metabolism of the amyloid precursor protein (APP) and to reduce the secretion of beta-amyloid peptides (Abeta) that are associated with Alzheimer's disease. Whereas X11alpha interacts with APP via its phosphotyrosine-binding domain, recent reports indicate that additional regulatory interactions involve the N terminus of X11. Here we report that the syntaxin-1a-binding protein Munc18a, which interacts with the Munc18a-interacting domain (MID) at the N terminus of X11, strongly regulates the actions of X11 on APP metabolism. When co-expressed with X11alpha, Munc18a potentiated the retention of APP and suppression of Abeta secretion by X11alpha. As a result, the constitutive release of Abeta40 was nearly abolished. Experiments using N terminus deletion mutants of X11alpha/beta and the MID-deficient X11gamma revealed that the majority of the regulatory effect by Munc18a occurred independent of a direct interaction of Munc18a with X11, although the presence of X11 was required. Munc18a expression induced a small increase in beta-secretase activity, whereas it also intensified the reduction in Abeta40 secretion by X11alpha. These data indicate that Munc18a in concert with X11 acts to suppress gamma-secretase processing. We conclude that Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201823200"xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Ho C.S."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Turner R.S."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Marinescu V."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Gaut J.R."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Steinhilb M.L."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/author | "Stuenkel E.L."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/pages | "27021-27028"xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/title | "Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism."xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12016213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12016213 |
| http://purl.uniprot.org/citations/12016213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12016213 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-12016213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12016213 |
| http://purl.uniprot.org/uniprot/#_P61764-mappedCitation-12016213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12016213 |
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| http://purl.uniprot.org/uniprot/#_A0A8F9R5D5-mappedCitation-12016213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12016213 |
| http://purl.uniprot.org/uniprot/#_B4DGD0-mappedCitation-12016213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12016213 |
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