| http://purl.uniprot.org/citations/12019269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12019269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12019269 | http://www.w3.org/2000/01/rdf-schema#comment | "PYRIN-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction proteins. We report here that PYPAF7 is a novel PYPAF protein that activates inflammatory signaling pathways. The expression of PYPAF7 is highly restricted to immune cells, and its gene maps to chromosome 19q13.4, a locus that contains a cluster of genes encoding numerous PYPAF family members. Co-expression of PYPAF7 with ASC results in the recruitment of PYPAF7 to distinct cytoplasmic loci and a potent synergistic activation of NF-kappa B. To identify other proteins involved in PYPAF7 and ASC signaling pathways, we performed a mammalian two-hybrid screen and identified pro-caspase-1 as a binding partner of ASC. Co-expression of PYPAF7 and ASC results in the synergistic activation of caspase-1 and a corresponding increase in secretion of interleukin-1 beta. In addition, PYPAF1 induces caspase-1-dependent cytokine processing when co-expressed with ASC. These findings indicate that PYPAF family members participate in inflammatory signaling by regulating the activation of NF-kappa B and cytokine processing."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203915200"xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203915200"xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Bertin J."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Bertin J."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "DiStefano P.S."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "DiStefano P.S."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Lora J.M."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Lora J.M."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Al-Garawi A."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Al-Garawi A."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Briskin M."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Briskin M."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Geddes B.J."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Geddes B.J."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Manji G.A."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Manji G.A."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Merriam S."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Merriam S."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Grenier J.M."xsd:string |
| http://purl.uniprot.org/citations/12019269 | http://purl.uniprot.org/core/author | "Grenier J.M."xsd:string |