| http://purl.uniprot.org/citations/12021769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12021769 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell death in higher organisms is negatively regulated by Inhibitor of Apoptosis Proteins (IAPs), which contain a ubiquitin ligase motif, but how ubiquitin-mediated protein degradation is regulated during apoptosis is poorly understood. Here, we report that Drosophila melanogaster IAP1 (DIAP1) auto-ubiquitination and degradation is actively regulated by Reaper (Rpr) and UBCD1. We show that Rpr, but not Hid (head involution defective), promotes significant DIAP1 degradation. Rpr-mediated DIAP1 degradation requires an intact DIAP1 RING domain. Among the mutations affecting ubiquitination, we found ubcD1, which suppresses rpr-induced apoptosis. UBCD1 and Rpr specifically bind to DIAP1 and stimulate DIAP1 auto-ubiquitination in vitro. Our results identify a novel function of Rpr in stimulating DIAP1 auto-ubiquitination through UBCD1, thereby promoting its degradation."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb795"xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/author | "Ciechanover A."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/author | "Steller H."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/author | "Bergmann A."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/author | "Gonen H."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/author | "Ryoo H.D."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/pages | "432-438"xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/title | "Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1."xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12021769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12021769 |
| http://purl.uniprot.org/citations/12021769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12021769 |
| http://purl.uniprot.org/uniprot/Q24306#attribution-217AFDC4347C9E33E12501856938A470 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/Q24306#attribution-73AD219E7E3E9D00F6C7FD1EEE2E83A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/Q24106#attribution-73AD219E7E3E9D00F6C7FD1EEE2E83A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/Q24475#attribution-10E4C9FC07FEA6F7498242A62AD2C6B6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/Q24475#attribution-217AFDC4347C9E33E12501856938A470 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/Q24475#attribution-73AD219E7E3E9D00F6C7FD1EEE2E83A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/P25867#attribution-217AFDC4347C9E33E12501856938A470 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/P25867#attribution-73AD219E7E3E9D00F6C7FD1EEE2E83A8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/P25867#attribution-DDC4C80D132289926721722AA79A9B3D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12021769 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ0-mappedCitation-12021769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12021769 |