| http://purl.uniprot.org/citations/12023295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12023295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12023295 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian cells contain potent activity for removal of 3'-phosphoglycolates from single-stranded oligomers and from 3' overhangs of DNA double strand breaks, but no specific enzyme has been implicated in such removal. Fractionated human whole-cell extracts contained an activity, which in the presence of EDTA, catalyzed removal of glycolate from phosphoglycolate at a single-stranded 3' terminus to leave a 3'-phosphate, reminiscent of the human tyrosyl-DNA phosphodiesterase hTdp1. Recombinant hTdp1, as well as Saccharomyces cerevisiae Tdp1, catalyzed similar removal of glycolate, although less efficiently than removal of tyrosine. Moreover, glycolate-removing activity could be immunodepleted from the fractionated extracts by antiserum to hTdp1. When a plasmid containing a double strand break with a 3'-phosphoglycolate on a 3-base 3' overhang was incubated in human cell extracts, phosphoglycolate processing proceeded rapidly for the first few minutes but then slowed dramatically, suggesting that the single-stranded overhangs gradually became sequestered and inaccessible to hTdp1. The results suggest a role for hTdp1 in repair of free radical-mediated DNA double strand breaks bearing terminally blocked 3' overhangs."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m204688200"xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m204688200"xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Zhou T."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Zhou T."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Lees-Miller S.P."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Lees-Miller S.P."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Pouliot J.J."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Pouliot J.J."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Povirk L.F."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Povirk L.F."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Inamdar K.V."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Inamdar K.V."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Rasouli-Nia A."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/author | "Rasouli-Nia A."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/pages | "27162-27168"xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/pages | "27162-27168"xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/title | "Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1."xsd:string |
| http://purl.uniprot.org/citations/12023295 | http://purl.uniprot.org/core/title | "Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1."xsd:string |