| http://purl.uniprot.org/citations/12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12023887 | http://www.w3.org/2000/01/rdf-schema#comment | "We have found previously that ascorbic acid (vitamin C), as well as acting as a radical scavenger, may modulate the expression of several genes [i.e. fra-1, glutathione S-transferase Pi (GSTpi) and Mut L homologue-1 (MLH1)] in human keratinocytes. In the present paper, we demonstrate that MLH1, as well as its downstream target p73, can be positively modulated by this antioxidant vitamin, indeed, up-regulation of the two mRNAs was observed after just 2 h, and increased further up to 16 h of treatment. Modulation of MLH1 and p73 gene expression improves cellular susceptibility to apoptosis triggered by the DNA-damaging agent cisplatin. Indeed, in ascorbate-supplemented cells, increased cisplatin-induced apoptosis was seen, involving activation of the MLH1/c-Abl/p73 signalling cascade. Our results were further confirmed by studies performed on genetically defined mutants, i.e. mouse embryo fibroblasts derived from knock-out animals for c-Abl or p53, as well as human colon carcinoma cell lines deficient in MLH1. The increased sensitivity to cisplatin observed in ascorbate-loaded cells appeared to be dependent exclusively on MLH1 and c-Abl expression, and independent of p53. These data suggest a potential mechanism accounting for the anti-carcinogenic and anti-cancer activities of vitamin C."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20011713"xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Avigliano L."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Melino G."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "de Laurenzi V."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Costanzo A."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Levrero M."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Catani M.V."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/author | "Savini I."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/pages | "441-447"xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/title | "Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://purl.uniprot.org/core/volume | "364"xsd:string |
| http://purl.uniprot.org/citations/12023887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12023887 |
| http://purl.uniprot.org/citations/12023887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12023887 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFW9-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A5JTV1-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A1YR10-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A8W2I7-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A8W2J0-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A8W2J3-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |
| http://purl.uniprot.org/uniprot/#_A8W2J6-mappedCitation-12023887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12023887 |