| http://purl.uniprot.org/citations/12027803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12027803 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of both Myc and nuclear factor kappaB (NF-kappaB) families of transcription factors are found overexpressed or inappropriately activated in many forms of human cancer. Furthermore, NF-kappaB can induce c-Myc gene expression, suggesting that the activities of these factors are functionally linked. We have discovered that both c-Myc and v-Myc can induce a previously undescribed, truncated form of the RelA(p65) NF-kappaB subunit, RelA(p37). RelA(p37) encodes the N-terminal DNA binding and dimerization domain of RelA(p65) and would be expected to function as a trans-dominant negative inhibitor of NF-kappaB. Surprisingly, we found that RelA(p37) no longer binds to kappaB elements. This result is explained, however, by the observation that RelA(p37), but not RelA(p65), forms a high-molecular-mass complex with c-Myc. These results demonstrate a previously unknown functional and physical interaction between RelA and c-Myc with many significant implications for our understanding of the role that both proteins play in the molecular events underlying tumourigenesis."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020444"xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Wilson B.J."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Crouch D.H."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Perkins N.D."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Gillespie P.J."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Webster G.A."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/author | "Chapman N.R."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/pages | "459-469"xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/title | "A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with the proto-oncogene c-Myc."xsd:string |
| http://purl.uniprot.org/citations/12027803 | http://purl.uniprot.org/core/volume | "366"xsd:string |
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