| http://purl.uniprot.org/citations/12029091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12029091 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyunsaturated fatty acids (PUFAs) suppress immune responses and inhibit T cell activation through largely unknown mechanisms. The displacement of signaling proteins from membrane lipid rafts has recently been suggested as underlying PUFA-mediated T cell inhibition. We show here that PUFA treatment specifically interferes with T cell signal transduction by blocking tyrosine phosphorylation of LAT (linker for activation of T cells) and phospholipase Cgamma1. A significant fraction of LAT was displaced from rafts by PUFA treatment along with other signaling proteins. However, retaining LAT alone in lipid rafts effectively restored phospholipase Cgamma1/calcium signaling in PUFA-treated T cells. These data reveal LAT displacement from lipid rafts as a molecular mechanism by which PUFAs inhibit T cell signaling and underline the predominant importance of LAT localization in rafts for efficient T cell activation."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203343200"xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/author | "Staffler G."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/author | "Stulnig T.M."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/author | "Waldhausl W."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/author | "Zeyda M."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/pages | "28418-28423"xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/title | "LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids."xsd:string |
| http://purl.uniprot.org/citations/12029091 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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