| http://purl.uniprot.org/citations/12032081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12032081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12032081 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier. A sumoylation-deficient point mutant (HDAC4-K559R) shows a slightly impaired ability to repress transcription as well as reduced histone deacetylase activity. The ability of HDAC4 to self-aggregate is a prerequisite for proper sumoylation in vivo. Calcium/calmodulin-dependent protein kinase (CaMK) signalling, which induces nuclear export, abrogates SUMO-1 modification of HDAC4. Moreover, the modification depends on the presence of an intact nuclear localization signal and is catalysed by the nuclear pore complex (NPC) RanBP2 protein, a factor newly identified as a SUMO E3 ligase. These findings suggest that sumoylation of HDAC4 takes place at the NPC and is coupled to its nuclear import. Finally, modification experiments indicate that the MEF2-interacting transcription repressor (MITR) as well as HDAC1 and -6 are similarly SUMO modified, indicating that sumoylation may be an important regulatory mechanism for the control of transcriptional repression mediated by both class I and II HDACs."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.11.2682"xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.11.2682"xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Mueller S."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Mueller S."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Mathieu M."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Mathieu M."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Dejean A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Dejean A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Gast A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Gast A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Melchior F."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Melchior F."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Harel-Bellan A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Harel-Bellan A."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Seeler J.-S."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Seeler J.-S."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Kirsh O."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Kirsh O."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Miska E."xsd:string |
| http://purl.uniprot.org/citations/12032081 | http://purl.uniprot.org/core/author | "Miska E."xsd:string |