| http://purl.uniprot.org/citations/12032348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12032348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12032348 | http://www.w3.org/2000/01/rdf-schema#comment | "The inositol trisphosphate (InsP(3)) receptor (InsP(3)R) is a ubiquitously expressed intracellular Ca(2+) channel that mediates complex cytoplasmic Ca(2+) signals, regulating diverse cellular processes, including synaptic plasticity. Activation of the InsP(3)R channel is normally thought to require binding of InsP(3) derived from receptor-mediated activation of phosphatidylinositol lipid hydrolysis. Here we identify a family of neuronal Ca(2+)-binding proteins as high-affinity protein agonists of the InsP(3)R, which bind to the channel and activate gating in the absence of InsP(3). CaBP/caldendrin, a subfamily of the EF-hand-containing neuronal calcium sensor family of calmodulin-related proteins, bind specifically to the InsP(3)-binding region of all three InsP(3)R channel isoforms with high affinity (K(a) approximately 25 nM) in a Ca(2+)-dependent manner (K(a) approximately 1 microM). Binding activates single-channel gating as efficaciously as InsP(3), dependent on functional EF-hands in CaBP. In contrast, calmodulin neither bound with high affinity nor activated channel gating. CaBP1 and the type 1 InsP(3)R associate in rat whole brain and cerebellum lysates, and colocalize extensively in subcellular regions in cerebellar Purkinje neurons. Thus, InsP(3)R-mediated Ca(2+) signaling in cells is possible even in the absence of InsP(3) generation, a process that may be particularly important in responding to and shaping changes in intracellular Ca(2+) concentration by InsP(3)-independent pathways and for localizing InsP(3)-mediated Ca(2+) signals to individual synapses."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.102006299"xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.102006299"xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Foskett J.K."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Foskett J.K."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Haeseleer F."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Haeseleer F."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Mak D.-O.D."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Mak D.-O.D."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "McBride S."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "McBride S."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Vardi N."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/author | "Vardi N."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/pages | "7711-7716"xsd:string |
| http://purl.uniprot.org/citations/12032348 | http://purl.uniprot.org/core/pages | "7711-7716"xsd:string |