| http://purl.uniprot.org/citations/12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12034730 | http://www.w3.org/2000/01/rdf-schema#comment | "The Smad proteins are key intracellular effectors of transforming growth factor-beta (TGF-beta) cytokines. The ability of Smads to modulate transcription results from a functional cooperativity with the coactivators p300/cAMP-response element-binding protein-binding protein (CBP), or the corepressors TGIF and Ski. The c-Jun N-terminal kinase (JNK) pathway, another downstream target activated by TGF-beta receptors, has also been suggested to inhibit TGF-beta signaling through interaction of c-Jun with Smad2 and Smad3. Here we show that c-Jun directly interacts with Ski to enhance the association of Ski with Smad2 in the basal state. Interestingly, TGF-beta signaling induces dissociation of c-Jun from Ski, thereby relieving active repression by c-Jun. Moreover, activation of JNK pathway suppressed the ability of TGF-beta to induce dissociation of c-Jun from ski. Thus, the formation of a c-Jun/Ski complex maintains the repressed state of Smad2-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling by the JNK cascade."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202831200"xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Mauviel A."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Prunier C."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Atfi A."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Lallemand F."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Ferrand N."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Pessah M."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/author | "Marais J."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/pages | "29094-29100"xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/title | "c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12034730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12034730 |
| http://purl.uniprot.org/citations/12034730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12034730 |
| http://purl.uniprot.org/uniprot/#_E9PZV6-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_E9Q5P9-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_B1AUF1-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_B1AUF2-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_E9PXA8-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_B7Z5N5-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |
| http://purl.uniprot.org/uniprot/#_E9Q3M0-mappedCitation-12034730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12034730 |