| http://purl.uniprot.org/citations/12034878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12034878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12034878 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional coactivators implicated in gene activation by the thyroid hormone receptor (TR) include members of the p160/steroid receptor coactivator (SRC) family of proteins, p300, and the multisubunit TR-associated protein (TRAP)/Mediator complex. We investigated the temporal recruitment of these cofactors to mammalian thyroid hormone (T3)-responsive promoters in vivo. We show that upon T3 treatment, TR recruits all three types of coactivators to specific promoters in at least two sequential steps: p160/SRC proteins and p300 are recruited first and rapidly induce histone acetylation, followed by the recruitment of the TRAP/Mediator complex. Interestingly, inhibition of histone deacetylase activity with trichostatin A elicited a more rapid promoter recruitment of the TRAP/Mediator complex but not p160/SRC proteins. T3-dependent gene expression assays indicate that all three coactivators are targeted to a promoter before significant activation occurs. These findings thus suggest that histone acetylation may be a prerequisite for TRAP/Mediator recruitment and function at specific T3-responsive mammalian promoters."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.122004799"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.122004799"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/author | "Sharma D."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/author | "Sharma D."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/author | "Fondell J.D."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/author | "Fondell J.D."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/pages | "7934-7939"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/pages | "7934-7939"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/title | "Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/title | "Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo."xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/12034878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12034878 |
| http://purl.uniprot.org/citations/12034878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12034878 |
| http://purl.uniprot.org/citations/12034878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12034878 |
| http://purl.uniprot.org/citations/12034878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12034878 |
| http://purl.uniprot.org/uniprot/Q15648 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12034878 |
| http://purl.uniprot.org/uniprot/A0A8I6A4N6#attribution-622BC0325D6B41FF57E42212C9126A81 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12034878 |