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http://purl.uniprot.org/citations/12037309http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12037309http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12037309http://www.w3.org/2000/01/rdf-schema#comment"Bothrombin, a snake-venom serine protease, specifically cleaves fibrinogen, releasing fibrinopeptide A to form non-crosslinked soft clots, aggregates platelets in the presence of exogenous fibrinogen and activates blood coagulation factor VIII. Bothrombin shares high sequence homology with other snake-venom proteases such as batroxobin (94% identity), but only 30 and 34% identity with human alpha-thrombin and trypsin, respectively. Single crystals of bothrombin have been obtained and X-ray diffraction data have been collected at the Laboratorio Nacional de Luz Sincrotron to a resolution of 2.8 A. The crystals belong to the space group P2(1)2(1)2(1), with unit-cell parameters a = 94.81, b = 115.68, c = 155.97 A."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.org/dc/terms/identifier"doi:10.1107/s0907444902003645"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.org/dc/terms/identifier"doi:10.1107/s0907444902003645"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Arni R.K."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Arni R.K."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Watanabe L."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Watanabe L."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Bortoleto R.K."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Bortoleto R.K."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Vieira D.F."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/author"Vieira D.F."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/name"Acta Crystallogr. D"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/name"Acta Crystallogr. D"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/pages"1036-1038"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/pages"1036-1038"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/title"Crystallization of bothrombin, a fibrinogen-converting serine protease isolated from the venom of Bothrops jararaca."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/title"Crystallization of bothrombin, a fibrinogen-converting serine protease isolated from the venom of Bothrops jararaca."xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/12037309http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/12037309http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12037309
http://purl.uniprot.org/citations/12037309http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12037309